In August of this year, the dermatology team at the Skin Center of Srinakharinwirot Medical School successfully completed the efficacy test for the treatment of hyperpigmentation utilizing Detachable Dissolvable Microneedles containing vitamin C. The study was approved by the research ethic committee of Srinakharinwirot University (SWEC/F-095/2564). All methods were performed in accordance with the relevant guidelines and regulations of the Declarations of Helsinki. The tests on sixty volunteers were conducted during July–August 2021. A Colorimeter was used to assess melanin index and luminance at weeks 0 (baseline), 1, 2, 3 and 4. The use of vitamin C-loaded detachable microneedles resulted in a significant improvement in skin hyperpigmentation in comparison to the baseline. The findings were published in Scientific report, a journal under the Nature publisher. In addition to hyperpigmentation treatment, the research provides proof of rapid skin surface resealing following the administration of detachment microneedles, in contrast to the visible skin surface damage caused by traditional microneedles that need a lengthy administration period. The link to the article is https:// doi. org/ 10. 1038/ s41598- 021- 03503-5.