In the study carried out at the Department of Dermatology, Center of Experimental and Applied Cutaneous Physiology (CCP), Charité Universitätsmedizin Berlin, in collaboration with Chulalongkorn University, two intradermal drug delivery systems, the Detachable  Dissolvable Microneedles and conventional topical administration, were compared. The amount of retinoid in the epidermis and dermis after conventional topical administration of retinoid solution was significantly less than that after the administration of retinoid-loaded detachable microneedles. It is noted here that the test was carried out with the same administered retinoid dose for the two routes. This study advocates that the platform of detachable microneedles can provide a rapid and convenient administration of active pharmaceutical ingredients into the dermis for the purpose of curing or physiological alteration of the skin tissue condition.